Hydroxypropyl beta-cyclodextrin, e mohiotia ana ko (2-hydroxypropyl) -β-cyclodextrin, he ngota hauwai kei roto i nga roopu 2-, 3-, me te 6-hydroxyl o nga toenga huka i roto i te β-cyclodextrin (β-CD) ka whakakapihia e te hydroxypropyl ki hydroxypropoxy. Ko te HP-β-CD ehara i te mea he pai te awe o te envelopu ki runga i te maha o nga puhui penei i te β-CD, engari he painga ano hoki o te wairewa teitei o te wai me te whakapai ake i te reiti tuku me te koiora o nga raau taero kapi i roto i te vivo. I tua atu, ko te HP-β-CD he rongoa rongoa me nga raraunga haumaru tino nui i kohia, kaore he paanga kino. Ka taea hoki te whakamahi HP-β-CD hei whakamarumaru pūmua me te whakapumau.
Ko te Hydroxypropyl beta-cyclodextrin he ma, he ma, he amorphous ranei he paura tioata; He kakara, he paku reka; He kaha te whakauru makuku. Ko tenei hua he ngawari ki te wai, ngawari ki te mewaro, te waihano, tata korekore ki te acetone, trichloromethane.
Te memehatanga ohydroxypropyl -B-cyclodextrini roto i te wai he tino pai, a ko te tohu whakakapinga o te 4 me runga ake ka taea te whakauru ki te wai ahakoa te rahinga, ka taea hoki te rewa ki te 50% ewaro me te methanol. He tino hygroscopicity. Engari he iti noa te mahi mata me te mahi hemolytic. Karekau he riri ki te uaua, he pai te whakaniko i te whakarewa me te rongoa rongoa mo te werohanga.
Hei aha te Hydroxypropyl beta-cyclodextrin?
I te mara kai me nga mea kakara
Ka taea e te Hydroxypropyl beta-cyclodextrin te whakapai ake i te pumau me te mahi mo te wa roa o nga ngota ngota kai, te hipoki, te whakatika ranei i te kakara kino me te reka o nga ngota ngota kai, me te whakapai ake i te tukanga whakaputa me te kounga o te hua.
I roto i nga whakapaipai
Ko nga rauemi mata o nga mea whakapaipai ka taea te whakamahi hei whakapumau, whakaehunga, deodorizers, me etahi atu, ka taea te whakaiti i te whakaongaonga o nga ngota pararopi i roto i nga mea whakapaipai i runga i te kiri me te kopa mucous membrane, te whakarei ake i te pumau o nga kai kaha, me te aukati i te whakaheke me te whakapouri o nga matūkai. . He ahua hygroscopicity.
I te waahi rongoa
Hydroxypropyl beta-cyclodextrinka taea te whakapai ake i te wairewa o nga raau taero kore, te whakanui ake i te pumau o te raau taero, te whakapai ake i te koiora o te tarukino, te whakanui ake i te kaha o nga whakaritenga tarukino, te whakaheke ranei i te inenga, te whakatika, te whakahaere ranei i te tere tuku o nga raau taero, me te whakaiti i te paitini o te tarukino. Ka taea te whakamahi hei kawe rongoa waha, werohanga, punaha tuku tarukino mucosal (tae atu ki te mucosa nasal, rectum, cornea, me etahi atu), nga punaha tuku tarukino transdermal absorption, lipophilic nga raau taero, ka taea hoki te whakamahi hei parenga pūmua me pūmau.
Te wa tuku: Oketopa-20-2023